Maternal Age: Region

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Cases with more than one anomaly within a group are counted only once. Numbers reflect cases where that anomaly occurs in a baby of a mother who falls into that age range, expressed as a percentage of all cases of that anomaly notified to us. The maternal age is taken as being that at the end of the pregnancy.

Region < 20 20 - 24 25 - 29 30 - 34 35 - 39 40 - 44 > 44 Not Known
A: Neurological 8.8 19.8 22.8 26.2 17.9 3.7 0.2 0.5
All neural tube defects 9.2 18.6 25.0 26.3 17.5 2.6 0.4 0.2
anencephalus 8.1 21.0 26.3 23.7 17.2 3.2 0.5  
spina bifida 10.7 15.6 25.3 27.6 17.8 2.2 0.4 0.4
encephalocele 7.5 20.8 20.8 28.3 20.8 1.9    
Congenital hydrocephalus 6.3 17.8 21.5 31.1 18.5 4.1 0.4 0.4
Muscular dystrophy       100.0        
Duchenne MD       100.0        
B: Eye Ear Face Neck 5.8 16.7 22.4 26.6 21.6 5.8 0.3 0.8
All eye 7.3 16.7 23.0 27.9 19.9 3.5   1.7
anophthalmos / microphthalmos 6.8 22.7 20.5 20.5 25.0 4.5    
congenital cataract 6.9 17.2 20.7 32.8 15.5 1.7   5.2
anomalies surrounding structures 4.2 12.5 29.2 35.4 12.5 4.2   2.1
All ear 7.8 17.5 22.3 30.1 17.5 3.9 1.0  
external ear anomalies 5.9 23.5 20.6 23.5 23.5 2.9    
sensorineural hearing loss 11.5 19.2 23.1 26.9 11.5 7.7    
C: Circulatory 7.1 16.7 25.4 26.7 17.7 5.4 0.5 0.6
Disordered circulation 11.2 18.9 16.8 28.0 20.3 4.9    
All septal defects 6.8 16.1 24.9 27.6 17.7 5.8 0.6 0.4
ASD (all types) 7.7 15.1 24.9 25.7 19.3 6.6 0.8  
VSD 7.0 16.8 25.4 28.2 16.7 5.0 0.4 0.5
AVSD 6.4 12.8 17.0 24.1 24.8 12.1 2.8  
All complex cyanotic CHD 8.0 14.1 30.7 27.6 18.1 1.5    
transposition great vessels 6.2 11.5 33.6 31.9 15.9 0.9    
tetralogy of Fallot 10.5 17.4 26.7 22.1 20.9 2.3    
All heart valve anomalies 8.8 14.8 23.6 29.0 16.8 5.7 0.8 0.6
pulmonary valve anomalies 10.0 16.9 22.4 26.0 16.0 6.4 1.4 0.9
tricuspid valve anomalies 7.2 15.5 25.8 24.7 21.6 5.2    
mitral valve anomalies 6.7 15.6 20.0 40.0 11.1 4.4 2.2  
aortic valve anomalies 7.9 12.1 23.0 33.9 15.2 6.1 1.2 0.6
All vessel anomalies 7.9 17.8 23.6 25.5 19.4 5.3 0.3 0.3
pulmonary artery anomalies 10.0 19.1 21.8 24.5 19.1 5.0   0.5
aorta anomalies 7.3 15.3 22.0 27.1 22.3 5.4 0.6  
All chamber anomalies 8.4 18.2 26.4 27.9 13.1 4.9 0.7 0.4
hypoplastic left heart 5.0 24.0 26.4 28.9 9.9 4.1 0.8 0.8
hypoplastic right heart 15.4 23.1 38.5 15.4   7.7    
Conduction anomalies 6.8 20.3 23.0 24.3 21.6 4.1    
D: Respiratory 7.0 19.2 27.6 24.1 17.4 4.3 0.2 0.2
All airways 5.8 19.9 27.4 23.3 19.0 4.3 0.3  
All lung 10.3 17.5 27.3 26.3 13.4 4.6   0.5
cystic anomalies 14.3 16.1 19.6 23.2 17.9 7.1   1.8
agenesis 7.7 17.9 30.8 25.6 15.4 2.6    
hypoplasia 13.6 11.4 27.3 34.1 9.1 4.5    
E: Digestive 6.1 18.7 25.7 27.5 16.9 4.2 0.3 0.5
All clefting 6.9 20.1 26.1 26.1 14.9 4.9 0.5 0.6
lips 6.2 19.1 22.2 26.5 21.6 3.7 0.6  
alveolar 7.1 14.3 28.6 14.3 21.4 14.3    
isolated cleft palate 6.8 14.3 27.5 29.4 13.6 6.4 0.8 1.1
cleft palate with cleft lip 7.5 28.1 26.3 21.9 11.8 3.9   0.4
All oesophagus / stomach 2.2 23.0 18.7 29.5 20.9 5.8    
tracheo-oesophageal atresia, fistula, stenosis 2.5 23.0 18.9 28.7 20.5 6.6    
All intestines 6.3 18.9 25.8 25.4 19.5 3.3 0.2 0.6
duodenal atresia 3.2 19.0 19.0 30.2 27.0 1.6    
other small bowel atresias 4.0 14.0 18.0 36.0 22.0 6.0    
large bowel atresias 8.2 24.0 27.4 19.2 17.1 3.4   0.7
Hirschsprung's disease 5.2 13.8 25.9 29.3 20.7 5.2    
All digestive organs 4.7 19.5 24.2 35.2 14.1 2.3    
bilary atresia 4.8 14.3 33.3 28.6 14.3 4.8    
F: Urinary 6.3 17.9 26.1 29.0 15.7 4.2 0.2 0.6
All kidney 6.8 20.0 25.8 25.7 17.5 3.5 0.3 0.4
agenesis 7.4 23.5 17.9 25.9 21.6 3.7    
hypoplasia 7.3 9.8 31.7 26.8 22.0 2.4    
cystic 4.9 20.3 28.9 21.8 19.5 3.8 0.4 0.4
other specific kidney 7.8 14.7 26.5 30.2 16.3 3.7 0.4 0.4
All renal pelvis / ureters 6.0 14.9 27.0 33.1 14.0 4.5 0.2 0.3
pelviureteric obstruction 5.9 14.2 26.6 34.3 14.0 4.3 0.2 0.4
hydronephrosis, 10mm or over 5.4 15.3 26.1 32.5 17.2 3.4    
All bladder / urethra 6.9 19.3 27.2 27.2 12.4 6.4   0.5
epispadias   18.8 12.5 43.8 18.8 6.3    
G: Genital 6.2 18.2 26.7 27.7 16.6 4.1 0.1 0.3
Female 6.5 14.5 26.1 27.5 20.3 5.1    
Male 6.2 18.5 26.7 27.7 16.3 4.1 0.1 0.3
hypospadias 6.5 17.5 26.9 27.8 16.4 4.4 0.2 0.4
Intersex   17.4 34.8 30.4 13.0     4.3
H: Endocrine, metabolic 6.7 17.6 25.3 27.4 17.2 4.6 0.2 0.9
All thyroid 7.2 12.4 29.9 27.8 20.6 2.1    
hypothyroidism 7.2 12.4 29.9 27.8 20.6 2.1    
Phenylketonuria 20.0 20.0 60.0          
Cystic fibrosis 9.9 16.5 22.0 24.2 18.7 5.5   3.3
Adrenal 4.2 18.8 22.9 35.4 14.6 4.2    
J: Blood, immune, lymphatic 8.3 19.7 23.6 28.0 17.8 2.5    
Thalassaemia 5.3 21.1 15.8 47.4 5.3 5.3    
Sickle cell 14.7 14.7 23.5 17.6 20.6 8.8    
Immunodeficiency 100.0              
K: Skin 5.6 16.1 23.9 29.3 20.0 4.1   1.0
Cystic hygroma 5.1 12.7 23.3 26.7 24.6 6.4   1.3
L: Limbs 6.0 17.2 25.9 28.5 17.5 4.3 0.2 0.4
All upper limb 6.8 18.1 24.0 27.9 17.8 4.5 0.2 0.6
polydactyly 6.4 22.5 21.8 26.5 17.8 4.4   0.7
syndactyly 7.1 12.9 29.4 27.1 16.5 4.7   2.4
reduction defects 5.7 16.5 23.2 30.6 18.9 4.4   0.7
All lower limb 5.4 16.6 25.9 29.6 17.8 4.1 0.2 0.4
polydactyly 4.1 22.3 22.3 32.2 14.0 4.1 0.8  
syndactyly 3.3 20.0 27.4 29.3 14.9 5.1    
reduction defects 8.4 19.7 24.6 26.1 17.2 3.4   0.5
dysplastic hip 3.8 14.3 26.0 30.2 19.9 4.7   1.1
non-postural talipes 7.2 19.6 26.0 25.8 17.1 4.1   0.2
Non limb-specific 10.2 18.9 26.8 23.2 16.5 4.3    
M: Musculoskeletal 10.8 18.8 24.3 23.9 17.3 4.0 0.3 0.6
All abdominal wall defects 21.0 25.9 20.4 13.9 12.8 3.8 0.8 1.4
gastroschisis 35.4 35.4 18.4 3.8 4.4 0.6   1.9
exomphalos 9.0 16.2 22.2 21.6 21.0 7.8 1.2 1.2
All diaphragm 4.9 18.1 23.6 30.6 19.4 3.5    
hernia / agenesis 5.1 17.6 24.3 29.4 19.9 3.7    
All short stature 3.8 9.6 19.2 40.4 23.1 3.8    
achondroplasia 5.9   23.5 47.1 23.5      
All other specific musculoskeletal 7.2 17.1 26.2 25.9 19.0 4.0 0.2 0.3
skull, face & neck 7.2 15.9 26.4 24.2 19.6 5.9 0.2 0.7
thorax & trunk 6.1 12.7 27.6 30.9 19.9 2.8    
spine & pelvis 9.9 21.0 24.5 24.0 18.5 1.7 0.4  
N: Neoplastic 8.2 8.2 28.6 36.7 14.3 4.1    
O: Genetic / multi-site disorders 3.5 8.7 15.4 22.3 29.8 18.6 1.3 0.5
All chromosomal 3.2 7.7 14.7 22.2 30.8 19.5 1.3 0.5
trisomy 21 - Down's syndrome 1.6 5.2 10.1 20.6 36.7 24.3 1.4 0.3
trisomy 18 - Edwards' syndrome 3.1 5.7 13.8 17.6 32.4 23.6 2.8 0.9
trisomy 13 - Patau's syndrome 3.7 11.9 13.3 26.7 31.9 11.1 1.5  
triploidy / polyploidy 6.6 7.4 29.4 30.1 16.2 8.8 0.7 0.7
Turner's syndrome 9.2 17.2 21.3 25.3 19.0 7.5   0.6
Klinefelter's syndrome 6.3 6.3 12.5 12.5 28.1 28.1 6.3  
other anomalies sex chromosomes   13.2 13.2 22.6 20.8 26.4   3.8
deletions 5.5 12.7 27.6 28.2 21.0 4.4   0.6
other chromosome anomalies 3.0 8.2 14.8 22.0 29.1 20.9 1.4 0.5
Other genetic disorder 7.4 22.3 25.7 22.3 17.1 4.6 0.6  
P: Pregnancy related 7.4 17.4 27.4 26.1 17.8 3.0 0.9  
R: Infectious 15.7 6.7 25.8 22.5 27.0 2.2    
viral 23.3 13.3 23.3 16.7 23.3      
bacterial     71.4 14.3 14.3      
fungal                
S: Suggestion of underlying anomaly 7.8 13.5 18.1 29.4 24.5 6.0 0.4 0.4
hydrops 6.3 13.0 19.8 27.6 26.6 6.3 0.5  
                 
Additional anomalies collected by SWCAR                
pyloric stenosis 11.0 23.8 27.8 20.6 10.7 3.5   2.7
inguinal hernia 6.4 17.9 22.8 29.2 18.2 4.2 0.2 1.2
balanced translocation     17.6 52.9 23.5 5.9    
café au lait spot   25.0   25.0 25.0 25.0    
other branchial cleft malformations     50.0   50.0      
hydronephrosis >=5mm <10mm 6.3 18.4 26.1 29.5 16.5 2.8 0.2 0.2
vesicoureteric reflux 5.3 16.8 24.2 31.6 12.6 9.5    
congenital subluxation of hip 4.8 12.7 20.6 31.7 28.6 1.6